Reward System FAQs:

Q: Is a reward system a group of neural structures responsible for incentive salience , associative learning , and positive emotions, particularly ones which involve pleasure as a core component?

A: Yes, Reward is the attractive and motivational property of a stimulus that induces appetitive behavior – also known as approach behavior – and consummatory behavior.

Q: Is a reward system believed to be necessary for generating the sensation of an intense euphoria?

A: Yes.

Q: Is a reward system located primarily within the cortico-basal ganglia-thalamo-cortical loop?

A: Yes, the basal ganglia portion of the loop drives activity within the reward system.

Q: Is a reward system glutamatergic interneurons, GABAergic medium spiny neurons, and dopaminergic projection neurons, although other types of projection neurons contribute?

A: Yes, The reward system includes the ventral tegmental area, ventral striatum , dorsal striatum , substantia nigra , prefrontal cortex, anterior cingulate cortex, insular cortex, hippocampus, hypothalamus , thalamus , subthalamic nucleus, globus pallidus , ventral pallidum, parabrachial nucleus, amygdala, and the remainder of the extended amygdala.